An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1. (mesh:D016169)



Synonym Reference Specificity
LFA-1 Exact

Incoming Relations

Identifier Name Relation
HGNC:6155 ITGB2 partof
HGNC:6148 ITGAL partof

Outgoing Relations

Relation Identifier Name
isa FPLX:Integrins Integrins