A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. (mesh:D054684)



Synonym Reference Specificity
Phosphodiesterase 3 Exact
phosphodiesterase-3 Exact
PDE3 family Exact
PDE3 Exact
PDE 3 Exact
phosphodiesterase 3 Exact
Phosphodiesterase-3 Exact

Incoming Relations

Identifier Name Relation
HGNC:8779 PDE3B isa
HGNC:8778 PDE3A isa

Outgoing Relations

Relation Identifier Name