RSK

A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases. (mesh:D019893)

Cross-references

Synonyms

Synonym Reference Specificity
RSK Exact

Incoming Relations

Identifier Name Relation
FPLX:P90RSK P90RSK isa
FPLX:P70S6K P70S6K isa

Outgoing Relations

None available.