STAT

A family of transcription factors containing SH2 DOMAINS that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION. Once activated they dimerize and translocate into the CELL NUCLEUS where they influence GENE expression. They play a role in regulating CELL GROWTH PROCESSES and CELL DIFFERENTIATION. STAT transcription factors are inhibited by SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS and PROTEIN INHIBITORS OF ACTIVATED STAT. (mesh:D050791)

Cross-references

Synonyms

Synonym Reference Specificity
STAT Exact
STATs Exact

Incoming Relations

Identifier Name Relation
HGNC:11363 STAT2 isa
FPLX:STAT5 STAT5 isa
HGNC:11365 STAT4 isa
HGNC:11368 STAT6 isa
HGNC:11364 STAT3 isa
HGNC:11362 STAT1 isa

Outgoing Relations

None available.