TOP

Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoining strands of DNA in cells. These enzymes are important components of the DNA replication system. They are classified by their substrate specificities. DNA TOPOISOMERASE I enzymes act on a single strand of DNA. DNA TOPOISOMERASE II enzymes act on double strands of DNA. (mesh:D026942)

Cross-references

Synonyms

Synonym Reference Specificity
topoisomerase Exact

Incoming Relations

Identifier Name Relation
HGNC:29787 TOP1MT isa
HGNC:11986 TOP1 isa
HGNC:11993 TOP3B isa
FPLX:TOP2 TOP2 isa
HGNC:11992 TOP3A isa

Outgoing Relations

None available.