TOP2

DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex. (mesh:D004250)

Cross-references

Synonyms

Synonym Reference Specificity
topoisomerase II Exact

Incoming Relations

Identifier Name Relation
HGNC:11989 TOP2A isa
HGNC:11990 TOP2B isa

Outgoing Relations

Relation Identifier Name
isa FPLX:TOP TOP