An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN). (mesh:D039302)



Synonym Reference Specificity
alphavbeta3-integrin Exact
integrins alphavbeta3 Exact
vitronectin receptor Exact
alphavbeta3 integrins Exact
αvβ3 integrin Exact

Incoming Relations

Identifier Name Relation
HGNC:6156 ITGB3 partof
HGNC:6141 ITGA5 partof

Outgoing Relations

Relation Identifier Name
isa FPLX:Integrins Integrins